자료실
[Citation] Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice
작성자 : 관리자
등록일 : 2026.02.20조회수 : 9
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eCNTFR production and supplementation
We used an engineered CNTFR (eCNTFR)18 to achieve effective blockade of CLCF1. This blockade requires both increased binding of thedecoytoCLCF1anddecreasedbindingofCLCF1togp130andLIFR. The eCNTFR-Fc recombinant protein, containing eight consensus mutations (R110Q, T174P, S237F, I287F, Y177H, K178N, T268A, D269A), was synthesized by Y-Biologics (Y-Biologics, Deajeon, South Korea). Mice were treated with eCNTFR-Fc (10mg/kg) or PBS (vehicle) by i.p injection for 1 month, three times per week.
